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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: The EGFR-HSF1 axis accelerates the tumorigenesis of pancreatic cancer

Fig. 4

Pharmacological inhibition of HSF1 suppressed the formation of PanINs. a Representative histopathology (H&E staining), low-grade PanINs lesions (AB/PAS staining) and the IHC staining of amylase (acinar marker), CK19 (ductal marker) in the pancreas of vehicle KC mice, KC mice treated with long-term cerulein and KC mice treated with long-term cerulein plus KRIBB11. b-c Quantification of the number (b) and the diameter (c) of ductal-like structures per 400× field in the pancreas of vehicle KC mice, KC mice treated with long-term cerulein and KC mice treated with long-term cerulein plus KRIBB11. d-g Quantification of the percentage of the PanINs area (d), the AB/PAS-positive blue area (e), the amylase-positive acinar area (f) and the CK19-positive ductal area (g) per 400× field in the pancreas of vehicle KC mice, KC mice treated with long-term cerulein and KC mice treated with long-term cerulein plus KRIBB11. h Western blotting assay were performed to evaluate the effect of KRIBB11 on the expression of amylase, CK19 and HSP70 in KC mice (long-term cerulein) chronic pancreatitis tissues. Scale bars = 50 μm. nd = not detected, * P < 0.05

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