Skip to main content
Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: Hypoxia, endoplasmic reticulum stress and chemoresistance: dangerous liaisons

Fig. 4

HIF-1α- and UPR-targeting drugs as new chemosensitizing agents. Pharmacological inhbitors (red crosses) or activators (red arrows) of hypoxia-inducible factor-1α (HIF-1α) or unfolded protein response (UPR) actors - glucose-regulated protein 78 (GRP78), protein kinase R-like endoplasmic reticulum kinase/eukariotic initiating factor 2α/activating transcription factor-4 (PERK/eIF2α/ATF-4), inositol-requiring enzyme-1α/X-box-binding protein 1 (IRE1α/XBP-1) and activating transcription factor-6 (ATF6) – can be repurposed as chemosensitizing agents in hypoxic tumors. Δ9-THC: Δ9-tetrahydrocannabinol

Back to article page