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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: Exosomal circRNA-100338 promotes hepatocellular carcinoma metastasis via enhancing invasiveness and angiogenesis

Fig. 5

Exosome-delivered circRNA-100,338 significantly promoted HCC progression in vivo. a The relative expression of exosomal circRNA-100,338 in the serum of nude mice models. b Images of tumors in each group (n = 5). (C-G) We calculated the tumor volumes (c), microvessel density (d), MMP9 expression levels (e), the number of lung metastatic nodules (f) and positive rate of Ki67 in lung metastatic nodules (g) in each group. h The survival time of mouse treated control exosome group (siNC-exo), circRNA-100,338 knockdown exosome group (siCIRC-exo), IFNα group (siNC-exo + IFN-alpha) and both circRNA-100,338 knockdown exosome and IFNα group (siCIRC-exo + IFN-alpha). Significance was defined as P < .05 (*P < .05; **P < .01; ***P < .001)

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