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Table 1 Correlation of clinicopathological parameters with the alteration of circRNA_100,338 relative expression level in serum exosomes from HCC patients

From: Exosomal circRNA-100338 promotes hepatocellular carcinoma metastasis via enhancing invasiveness and angiogenesis

Clinicopathological parameters

n

CircRNA_100,338 alteration in serum exosomes

P

(Post/Pre)decrease group

(Post/Pre)increase group

(<  1.0, n = 23)

(≥ 1.0, n = 16)

Age

39

  

0.688

  < 58 y

18

10

8

 

  ≥ 58y

21

13

8

 

Gender

39

  

0.862

 Female

14

8

6

 

 Male

25

15

10

 

Viral hepatitis

39

  

1.000

 Type B

37

22

15

 

 Type B and C

2

1

1

 

Cirrhosis

39

  

0.677

 Yes

33

19

14

 

 No

6

4

2

 

AFP level

39

  

0.939

  < 20 ng/mL

10

6

4

 

  ≥ 20 ng/mL

29

17

12

 

Satellite

39

  

0.018

 Yes

18

7

11

 

 No

21

16

5

 

TNM stage

39

  

0.022

 I-II

19

15

4

 

 III-IVA

20

8

12

 

Vascular invasion

39

  

0.023

 Yes

16

6

10

 

 No

23

17

6

 

γ-Glutamyl transferase

39

  

0.522

  < 51 units/L

17

11

6

 

  ≥ 51 units/L

22

12

10

 

Lung metastasis#

39

  

0.004

 Yes

13

3

10

 

 No

26

20

6

 
  1. NOTE: HCC, hepatocellular carcinoma; Post/Pre: the ratio of exosomal circRNA-100,338 in HCC serum between one week pre-operation and three weeks post-operation. Significant difference: P < 0.05
  2. #Lung metastasis was found during follow-up