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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: Pin2 telomeric repeat factor 1-interacting telomerase inhibitor 1 (PinX1) inhibits nasopharyngeal cancer cell stemness: implication for cancer progression and therapeutic targeting

Fig. 4

Inhibition of miR-200b blocked the effects of PinX1overexpreesion on cell EMT, migration and invasion in nasopharyngeal CD133+ CSCs. a The mRNA expressions of E-cadherin, Vimentin, Snail1, Twist1, and Zeb1 in nasopharyngeal CD133+ CSCs transfected with empty vector and pcDNA3.0-PinX1 and pcDNA3.0-PinX1 + miR-200b inhibitor as determined by RT-qPCR. b The protein levels of E-cadherin, Vimentin, Snail1, Twist1, and Zeb1 in nasopharyngeal CD133+ CSCs transfected with empty vector and pcDNA3.0-PinX1 and pcDNA3.0-PinX1+ miR-200b inhibitor as determined by Western blot. The grey value of the protein was normalized to that of the corresponding GAPDH. c Cell migration and invasion following transfection as measured by Transwell assay. * p < 0.05 vs. control, ** p < 0.01 vs. control, *** p < 0.001 vs. control

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