Skip to main content
Fig. 9 | Journal of Experimental & Clinical Cancer Research

Fig. 9

From: The PLAGL2/MYCN/miR-506-3p interplay regulates neuroblastoma cell fate and associates with neuroblastoma progression

Fig. 9

Schematic summary of the interplay between miR-506-3p, PLAGL2, MYCN and RAs. PLAGL2 and MYCN form a positive regulatory loop, which promotes the transcriptional expression of each other. miR-506-3p acts upstream of the loop and directly targets PLAGL2 and inhibits PLAGL2 expression, which subsequently lead to reduced expression of MYCN. ATRA and 13-cis-RA up-regulate miR-506-3p expression and down-regulate the expression of PLAGL2 and MYCN. The four-molecule interplay network plays a role in modulating neuroblastoma cell differentiation, and the imbalance of this interplay may contribute to the progression of neuroblastoma in patients

Back to article page