Table 2 List of hypoxia-responsive miRNAs excepting miR-210
From: The interplay between HIF-1α and noncoding RNAs in cancer
MiRNAs | Cancer types | Status upon hypoxia | Regulatory mechanisms | Targets | Functions | References |
|---|---|---|---|---|---|---|
miR-21 | lung cancer | upregulation | transcriptional activation | PTEN | promotes colony formation, invasion and migration | [51] |
miR-382 | gastric cancer | upregulation | transcriptional activation | PTEN | promotes proliferation, migration and angiogenesis | [52] |
miR-224 | gastric cancer | upregulation | transcriptional activation | RASSF8 | promotes growth, migration and invasion | [53] |
miR-215 | glioblastoma | upregulation | transcriptinal proccessing via Drosha | KDM1B | promotes growth and neurospheres formation | [54] |
miR-494 | lung cancer | upregulation | transcriptional activation | PTEN | promotes migration | [55] |
miR-145 | bladder cancer | upregulation | transcriptional activation | N.A. | promotes apoptosis | [56] |
miR-191 | breast cancer | upregulation | transcriptional activation | TGFβ2, HuR | promotes proliferation, migration and survival | [57] |
miR-27a | gastric cancer | upregulation | transcriptional activation | N.A. | promotes proliferation, survival, multidrug resistance | [58] |
miR-424 | breast cancer | upregulation | transcriptional activation | PDCD4 | inhibits apoptosis and sensitivity to chemotherapy | [59] |
miR-21 | pancreatic cancer | upregulation | transcriptional activation | N.A. | promotes proliferation, inhibits apoptosis | [60] |
miR-185 | pancreatic cancer | upregulation | transcriptional activation | N.A. | N.A | [61] |
miR-210-3p | oral carcinoma | upregulation | transcriptional activation | RGMA | promotes proliferation | [62] |
miR-21 | oral carcinoma | upregulation | transcriptional activation | N.A. | promotes migration and invasion | [63] |
miR-107 | gastric cancer | upregulation | N.A. | N.A. | N.A. | [64] |
miR-204 | hepatocellular cancer | downregulation | N.A. | VASP | inhibits EMT, migration and invasion | [65] |
miR-34a | colorectal cancer | downregulation | transcriptional inhibition | PPP1R11 | inhibits EMT, invasion and migration | [66] |
miR-548an | pancreatic cancer | downregulation | transcriptional suppression via HDAC1 | Vimentin | inhibits the proliferation and invasion | [67] |
miR-200b | pan-cancer | downregulation | transcriptinal proccessing via Dicer | ZEB1/2 | inhibits EMT and invasion | [68] |
miR-33a | hepatocellular cancer | downregulation | N.A. | Twsit1 | inhibits EMT and invasion | [69] |
miR-205 | prostate cancer | downregulation | transcriptional inhibition | ZEB1/2 | inhibits EMT, motility, stemness and cancer-associated fibroblasts reactivity | [70] |
miR-101 | prostate cancer | downregulation | transcriptional inhibition | EZH2 | inhibits invasion, migration, proliferation | [71] |
miR-224-3p | glioblastoma, astrocytoma | downregulation | N.A. | ATG5 | inhibits mobility, promotes chemosensitivity | [72] |
miR-15a | lung cancer | downregulation | N.A. | N.A. | N.A. | [73] |