Table 3 List of hypoxia-responsive lncRNAs
From: The interplay between HIF-1α and noncoding RNAs in cancer
LncRNAs | Cancer types | Status upon hypoxia | Regulatory mechanisms | Functions | References |
|---|---|---|---|---|---|
lncRNA BC005927 | gastric cancer | upregulation | transcriptional activation | promotes invasion and metastasis | [81] |
lncRNA BX111 | pancreatic cancer | upregulation | transcriptional activation | promotes EMT, proliferation, migration and invasion | [82] |
lncRNA UCA1 | osteosarcoma | upregulation | transcriptional activation | promotes growth | [83] |
lncRNA UCA1 | bladder cancer | upregulation | transcriptional activation | promotes proliferation, migration and invasion, inhibits apoptosis | [84] |
lncRNA FALEC | prostate cancer | upregulation | transcriptional activation | promotes proliferation, migration and invasion | [85] |
lncRNA MALAT1 | HeLa and HEK-293T cells | upregulation | transcriptional activation | N.A. | [86] |
lncRNA ANRIL | osteosarcoma | upregulation | transcriptional activation | promotes invasion, inhibits apoptosis | [87] |
lncRNA NUTF2P3-001 | pancreatic cancer | upregulation | transcriptional activation | promotes viability, proliferation and invasion | [88] |
lncRNA HOTAIR | lung cancer | upregulation | transcriptional activation | promotes proliferation, migration and invasion | [89] |
lncRNA HOTAIR | pan-cancer | upregulation | transcriptional activation | N.A. | [90] |
lncRNA MEG3 | MCF-7 and HEK-293T cells | upregulation | transcriptional activation via recruiting CBP/p300 | promotes angiogenesis and the spheroid sprouting | [91] |
lncRNA H19 | glioblastoma | upregulation | transcriptional activation and recruits SP1 | promotes migration and invasion | [92] |
lncRNA LET | hepatocellular carcinoma | downregulation | histone deacetylation | promotes migration and invasion | [93] |