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Fig. 7 | Journal of Experimental & Clinical Cancer Research

Fig. 7

From: Enhanced histone H3 acetylation of the PD-L1 promoter via the COP1/c-Jun/HDAC3 axis is required for PD-L1 expression in drug-resistant cancer cells

Fig. 7

PD-L1 is positively correlated with c-Jun but negatively correlated with HDAC3 expression in cisplatin-resistant NSCLC tissues. The expression of PD-L1, c-Jun and HDAC3 in cisplatin-resistant and cisplatin-sensitive NSCLC tissues was detected by immunohistochemistry. Representative images are shown (a) (magnification: 20×). The average scores for PD-L1, c-Jun and HDAC3 expression were analyzed by modified quickscore assessment (b). c The correlations among PD-L1, c-Jun and HDAC3 expression in cisplatin-resistant NSCLC tumor tissues were analyzed by Pearson’s correlation coefficient. *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001

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