Fig. 1
From: Reversal of ABCB1-related multidrug resistance by ERK5-IN-1
The structure and cytotoxicity effects of ERK5-IN-1. a, the structure of ERK5-IN-1; b, the protein expression of ABCB1 and ABCG2 in pairs of parental and transporter overexpressing cell lines; c-f, MTT cytotoxicity assay was used to measure cell survival in: c, KB and ABCB1-overexpressing KBv200 cells; d, MCF-7 and ABCB1-overexpressing MCF-7/adr cells; e, HEK293/Vector and HEK293/ABCB1 cells; f, S1 and ABCG2-overexpressing S1-MI-80 cells. All cells were exposed to the full-range concentrations of ERK5-IN-1 for 68 h. Data points represent the means ± SD of at least three independent experiments performed in triplicate