Fig. 2

Potentiation of the antitumor effects of paclitaxel by ERK5-IN-1 in the KBv200 cell xenograft model. a, changes in tumor volume with time after cell inoculation. Data shown are means ± SD for each group of nine mice; b, tumor size, the photograph of xenografts was taken on the 19th day after implantation; c, changes of body weight after cell inoculation. Data shown are means ± SD for each group of nine mice after implantation; d, the average tumor weight of each group was calculated after the tumors were resected from mice. Data shown are mean ± SD for each group. Various treatments were given as follows: saline (q3d); paclitaxel (20 mg/kg, i.p. q3d); ERK5-IN-1 (25 mg/kg, gavage, q3d); ERK5-IN-1 (25 mg/kg, gavage, q3d, given 1 h before paclitaxel administration) and paclitaxel (20 mg/kg, i.p. q3d). **P < 0.01, significantly different from the control group