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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: Reversal of ABCB1-related multidrug resistance by ERK5-IN-1

Fig. 4

Effect of ERK5-IN-1 on efflux of Dox, ATPase activity and the [125I]-IAAP photolabeling of ABCB1. a, Time course of Dox efflux was measured in KB and KBv200 cells, with or without 0.4 μM ERK5-IN-1 or 10 μM VRP; b, the vanadate-sensitive ABCB1 ATPase activity in the presence of the indicated concentrations of ERK5-IN-1 was evaluated; c, ERK5-IN-1 competed for photolabeling of ABCB1 by [125I]-IAAP. The relative amount of [125I]-IAAP incorporated is plotted against the concentration of ERK5-IN-1 present. Each point represented the means ± SD of three independent experiments

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