Fig. 7
From: Reversal of ABCB1-related multidrug resistance by ERK5-IN-1
Schematic diagram of ERK5-IN-1 reversing MDR. Left, In the absence of ERK5-IN-1, ABCB1 transporters utilize energy derived from the hydrolysis of ATP to efflux their substrates crossing the membrane; Right, In the presence of ERK5-IN-1, ERK5-IN-1 increases the intracellular accumulation of the substrate drugs by blocking the efflux function of ABCB1