Fig. 3

DNMT3B is critical for FOXC1-induced HCC proliferation and metastasis. a-b Plate clone formation assay showed the proliferation abilities of the indicated HCC cells. c-d The migration and invasion abilities of the indicated HCC cells were analyzed by Transwell assays. e-f In vivo tumorigenesis assays, nude mice were divided into 4 groups (n = 10 mice per group). The volume and weight of tumors from different groups were showed. g-h Representative bioluminescent images and bioluminescence time course of the indicated groups are shown. i The number of metastatic lung nodules from different groups. j Typical images of hematoxylin and eosin (H&E) stained tissues for each group. Data are represented as mean ± S.D. of three experiments. *P < 0.05