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Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: FOXC1 promotes HCC proliferation and metastasis by Upregulating DNMT3B to induce DNA Hypermethylation of CTH promoter

Fig. 6

FOXC1 expression is positively correlated with 8-OHdG and p-ELK1 expression in human HCC tissues. a Representative images showing the 8-OHdG level, p-ELK1 level and FOXC1 expression in adjacent nontumor tissues and HCC tissues evaluated by IHC staining. Scale bars represent 400 μm (low magnification) and 100 μm (high magnification). b Association between the level of 8-OHdG or p-ELK1 and FOXC1 in HCC patients in cohort I (left) and cohort II (right). c-e Kaplan-Meier analysis of the correlation between the recurrence rate or overall survival time and 8-OHdG level or the concurrent 8-OHdG and FOXC1 expression in both cohorts. d-f Kaplan-Meier analysis of the correlation between the recurrence rate or overall survival time and p-ELK1 expression or the concurrent p-ELK1 and FOXC1 expression in both cohorts

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