FOXC1 promotes HCC proliferation and metastasis by Upregulating DNMT3B to induce DNA Hypermethylation of CTH promoter

Table 1 Correlation between CTH expression and clinicopathological characteristics of HCCs in two independent cohorts of human HCC tissues

Clinicopathological variables	Cohort I		P Value	Cohort II		P Value
	Tumor CTH expression			Tumor CTH expression
	Negative (n = 152)	Positive (n = 128)		Negative (n = 109)	Positive (n = 101)
Age	51.63 (9.148)	52.85 (10.966)	0.283	50.95 (10.857)	54.59 (9.943)	0.546
Sex
female	25	20	0.872	20	19	1.000
male	127	108		89	82
Serum AFP
≤ 20 ng/ml	24	25	0.433	19	31	0.034
> 20 ng/ml	128	103		90	70
Virus infection
HBV	108	85	0807	76	82	0.129
HCV	22	22		11	8
HBV + HCV	9	7		5	5
none	13	14		17	6
Cirrrhosis
absent	38	41	0.230	28	29	0.644
present	114	87		81	72
Child-pugh score
Class A	122	114	0.049	81	77	0.752
Class B	30	14		28	24
Tumor number
single	91	100	0.001	56	68	0.024
multiple	61	28		53	33
Maximal tumor size
≤ 5 cm	78	84	0.021	45	54	0.097
> 5 cm	74	44		64	47
Tumor encapsulation
absent	54	21	< 0.001	62	24	< 0.001
present	98	107		47	77
Microvascular invasion
absent	81	91	0.003	41	75	< 0.001
present	71	37		68	26
Tumor differentiation
I-II	100	107	0.001	76	91	< 0.001
III-IV	52	21		33	10
TNM stage
I-II	101	122	< 0.001	73	97	< 0.001
III	51	6		36	4

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