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Fig. 2 | Journal of Experimental & Clinical Cancer Research

Fig. 2

From: Hsa_circ_0005273 facilitates breast cancer tumorigenesis by regulating YAP1-hippo signaling pathway

Fig. 2

Hsa_circ_0005273 is highly expressed in BC and exerts oncogenic effects in BC cells. A-B Hsa_circ_0005273 was highly expressed in tumor tissues compared with adjacent normal tissues. C Expression of hsa_circ_0005273 in basal-like cohort, Her2-like cohort, luminal-A and luminal-B cohort, respectively. D Relative expression of hsa_circ_0005273 in BC cell lines. E Expression of hsa_circ_0005273 was confirmed by RT-qPCR in BC cells transfected with si-NC or si-circ_0005273. F-H Effect of si-circ_0005273 on proliferation in BC cells by MTT assay. I Effect of si-circ_0005273 on proliferation in BC cels by colony formation assay. J Effect of si-circ_0005273 on proliferation in BC cells by western blotting. K Cell migration assays were performed in MDA-MB-231 using transwell chambers. L Wound healing assays were performed in MDA-MB-231 treated with si-circ_0005273. M-O Cell cycle assays were performed in BC cells treated with si-circ_0005273. P Expression of hsa_circ_0005273 was confirmed by RT-qPCR in BC cells transfected with LV-vtctor or LV-circ_0005273. Q-S Effect of LV-circ_0005273 on proliferation in BC cell lines by MTT assay. T Effect of LV-circ_0005273 on proliferation in BC cell lines by colony formation assay. *p < 0.05, **p < 0.01,*** p < 0.001,**** p < 0.0001

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