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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: Hsa_circ_0005273 facilitates breast cancer tumorigenesis by regulating YAP1-hippo signaling pathway

Fig. 4

MiR-200a-3p is expressed at low levels and acts as a tumor suppressor in BC cells. A-B MiR-200a-3p had low expression in BC tissues compared with adjacent normal tissues. C Correlations between the expression of hsa_circ_0005273 and miR-200a-3p were found with Pearson’s correlation analysis in BC tissue samples (n = 120). D MiR-200a-3p had low expression in BC cell lines. E-G Effect of miR-200a-3p-mimics on proliferation in BC cells by MTT formation assay. H-I Effect of miR-200a-3p-inhibitor on proliferation in BC cells by colony formation assay. J Effect of miR-200a-3p-inhibitor on proliferation in BC cells by western blotting. K Wound healing assays were performed in MDA-MB-231 cell treated with miR-200a-3p-inhibitor. L Cell migration assays were performed in MDA-MB-231 cells using Transwell chambers. M-O Cell cycle assays were performed in BC cells treated with miR-200a-3p-inhibitor. *p < 0.05, **p < 0.01,*** p < 0.001,**** p < 0.0001

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