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Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: Hsa_circ_0005273 facilitates breast cancer tumorigenesis by regulating YAP1-hippo signaling pathway

Fig. 6

Hsa_circ_0005273 upregulated YAP1 through targeting miR-200a-3p. A-C the expression of miR-200a-3p increased and the expression of YAP1 decreased after hsa_circ_0005273 was downregulated by RT-qPCR in BC cells. D The protein levels of YAP1/p-YAP1 to be decreased after transfection of si-circ_0005273 in BC cells by Western blotting. E-H MiR-200a-3p-inhibitor rescued the promotive effects of hsa_circ_0005273 in BC cells by MTT assay and transwell assays. I-K MiR-200a-3p-inhibitor reversed cell cycle arrest induced by si-hsa_circ_0005273. L-N Western blotting showed that miR-200a-3p-inhibitor can partly rescue the low expression of YAP1, p-YAP1 and PCNA caused by si-circ_0005273 in BC cells. *p < 0.05, **p < 0.01,*** p < 0.001,**** p < 0.0001

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