Fig. 7
From: Hsa_circ_0005273 facilitates breast cancer tumorigenesis by regulating YAP1-hippo signaling pathway
Hsa_circ_0005273 inactivated Hippo signaling pathway. A-B LATS2/MST1 had low expression in BC tissues compared with adjacent normal tissues. C-D Negative correlations between the expression of hsa_circ_0005273 and LATS2/MST1 were found with Pearson’s correlation analysis in BC tissue samples (n = 45). E-G MRNA levels of MST1, LATS2 and YAP1 were tested in BC cells transfected with si-circ_0005273. H Protein levels of MST1, LATS1/2, YAP1 and their phosphorylation status were tested in BC cells transfected with si-circ_0005273. I Protein levels of YAP1 and p-YAP1 were tested in nucleus of si-circ_0005273 transfected BC cells. J, L, N and P Si-YAP1 rescued the promotive effects of hsa_circ_0005273 in BC cells by MTT assay and transwell assays. K, M and O Western blotting showed that si-YAP1 can partly rescue the high expression of YAP1 and p-YAP1 caused by LV-circ_0005273 in BC cells. *p < 0.05, **p < 0.01,*** p < 0.001,**** p < 0.0001