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Fig. 8 | Journal of Experimental & Clinical Cancer Research

Fig. 8

From: Hsa_circ_0005273 facilitates breast cancer tumorigenesis by regulating YAP1-hippo signaling pathway

Fig. 8

Hsa_circ_0005273 promotes BC tumor growth in vivo. A Hsa_circ_0005273 knockdown efficiency using shRNAs in MDA-MB-231 cells was verified by RT-qPCR. B Representative images of nude mice injected with MDA-MB-231 cells (4 mice per group). C Representative images of xenograft tumors in nude mice. D The growth curves of xenografts. E Average tumor weight of nude mice. F Extract protein from tumors and measuring the expression of YAP1, MST1, LAST1/2 and their phosphorylation status by Western blotting. G Immunohistochemistry (IHC) staining of YAP1, MST1 and LATS1/2 in xenografts. H The mechanism diagram was generated to illustrate the mechanism of hsa_circ_0005273-miR-200a-3p-YAP1-Hippo pathway in BC. *p < 0.05, **p < 0.01,*** p < 0.001,**** p < 0.0001

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