Fig. 4
Vitamin C sensitized BRAFMT thyroid cancer cells to PLX4032 induced cell cycle arrest. a 8505C, (b) BCPAP, (c) 8305C cells were treated with 0.25 Mm Vitamin C (VC) or 6 μM PLX4032 individually, 0.25 Mm VC and 4 μM PLX4032 in combination for 48 h, cell cycle arrest was measured by flow cytometry. Representative figures show the flow cytometric histograms (upper panels). Quantitative analysis of G2/M phase cells were shown in down panels. Data were presented as mean ± SD. *, P < 0.05; **/^^/##, P < 0.01. *: compared with control group; ^: compared with VC group; #: compared with PLX4032 group