Fig. 5
The combination of Vitamin C and PLX4032 synergistically inhibited the growth of BRAFMT thyroid cancer cells in vivo. a The growth of xenografts tumors in different group were shown in the line graph. b Representative images show the isolated tumors from mice in different groups (left panel), and the bar chart illustrated the tumor weight. c The levels of Ki-67 proteins in the indicated xenograft tumors by IHC assay (left panels). Statistical analysis of the percentage of Ki-67 positive cells was shown in right panels. Scale bars, 200 μm. d Representative H&E stained slices of kidney and liver sections from the indicated mice. Scale bars, 200 μm. Data were presented as mean ± SD. VC: Vitamin C. *, P < 0.05; **/##, P < 0.01; ***/^^^/###, P < 0.001. *: compared with control group; ^: compared with VC group; #: compared with PLX4032 group