Fig. 2
NRPs KO inhibits experimental RCC growth in immunocompetent and immunodeficient mice. a Experimental tumors in nude mice were obtained after injection of 3 × 105 control (Ctrl, 10 mice) or NRPs KO RENCA cells (5 mice for each condition). One NRP1 KO clone (4.1 7) and one NRP2 KO clone (5.1 8) were injected. Tumor incidence (percentage of mice with tumors) at the indicated times is presented. b Experimental tumors in immuno-competent Balb-C mice (5 mice per condition) were obtained after subcutaneous injection of 3 × 105 control (Ctrl) or the above-mentioned NRPs KO RENCA cells. The tumor volume is represented for the indicated time