Fig. 4From: Neuropilin 1 and Neuropilin 2 gene invalidation or pharmacological inhibition reveals their relevance for the treatment of metastatic renal cell carcinomaNRPa-308 exerts a wide range of anti-proliferative effect on primary ccRCC cells. a The effects of NRPa-308 on cell viability were tested on 786-O (786-O) and 786-O cells resistant to sunitinib (786R). b The relative expression of NRP1 and NRP2 mRNA in 786-O and 786R cells was evaluated in a RNA seq analysis and confirmed by RT qPCR. c The sensitivity of NRPa-308 was tested on already described primary cells [15] by MTT assays. d The relative mRNA levels were evaluated in 786-O cells that served as reference values (100%) and in the different primary cellsBack to article page