Fig. 2

Circ_0119872 promotes the malignancy of UM cells in vitro and in vivo. a The expression levels of circ_0119872 in OCM-1A and MUM-2B cells stably transfected with circ_0119872 overexpression or knockdown vector and the corresponding negative controls were detected by qRT-PCR. b Circ_0119872 promotes proliferation in UM cells, as determined by the CCK-8 assay. c Representative micrographs (left panel) and quantification (right panel) of EdU incorporation in UM cells as indicated. DAPI was used as a DNA/nuclear stain. d Representative images (left panel) and quantification (right panel) of HUVECs cultured on Matrigel-coated plates with conditioned medium from UM cells. e Representative images of tumours from the xenograft model in nude mice. f Tumour volumes were measured every third day. g Tumour weight were measured on the day 30. Bar graphs show the statistical analysis of three independent experiments (* P < 0.05)