Fig. 6

Metformin increased KLF10 expression and enhanced the radiosensitivity of OSCC cells. a-b Metformin reversed the decreased apoptosis (a) and accelerated DNA damage repair (b, scale bar = 20 μm) after irradiation caused by coculture with H-EVs. c Metformin increased KLF10 expression and regulated several key factors in irradiated OSCC cells treated with H-EVs. d Images of tumours in each group (n = 6). e Alterations in the tumour volume in each group (n = 6). f TUNEL-positive cell numbers were decreased after metformin supplementation