Fig. 2

Pediatric ALL proteome landscape in patients, PDXs and leukemic cell lines. a, b, c Hierarchical clustering map following unsupervised analyses on (A) 5554 quantified proteins, (B) 2832 quantified N termini, and (C) 2973 quantified phosphopeptides. Values plotted in heat maps are z-score normalized. Paired patient and xenograft samples are highlighted with blue border lines. The symbols ^ and * represent two samples, T-01-R1 and T-03-Dx, with low disease involvement of the bone marrow (< 10% of blasts), and their corresponding PDXs