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Table 2 Bone marrow morphology for clinical cohort

From: PDX models reflect the proteome landscape of pediatric acute lymphoblastic leukemia but divert in select pathways

Patient characteristics Sample features Bone marrow differential (per 100 cells counted)
Myeloid Erythroid Lymphoid
Leukemia Subtype Sample ID Total Cellularity Abnormal Infiltrate of immature cells Megakaryocytes Pro myelocyte Myelocyte Meta myelocyte Band cells Neutrophils Eosinophils Basophils Monocyte Pro Normoblast Early Normoblast Intermediate Normoblast Late Normoblast Blast cells Pro lymphocyte Lymphocyte B lymphocyte T lymphocyte Natural Killer Cells Plasma cells
B-ALL B-01-Dx Increased >95% Present Rare - - - - -   - - - - 2 - 94 - 4 - - - -
B-02-Dx Increased Present Decreased - - - - - - - 1 - - - - 97 - 2 - - - -
B-03-Dx Increased (100%) Present Present - - 1 - - - - 1 - - - - 93 - 5 - - - -
B-04-Dx Increased (>95%) Present Present - - 1 - - - - - - - 1 - 95 - 3 - - - -
B-05-R1 Increased Present (80%) Present - 1 4 2 2 2 - 4 - 4 12 - 68 - 1 - - - -
B-06-R2 Increased >95% Present Reduced - - - - - - - - - - 1 - 96 - 3 - - - -
B-06-R3 Increased >95% Present Present - 2 - - - - - - - 1 3 - 90 - 4 - - - -
B-07-R3 ND ND ND - - - - 2.31 0.77 - 0.77 - - - - - - 6.93 - - - -
B-08-R2 Increased (100%) Present Rare - - - - 1 - - - - - - rare 94 5 - - - - -
T-ALL T-01-Dx Increased >95% Present Present - - - 1 1 1 - - - 1 2 - 81 - 13 - - - -
T-01-R1 Increasesd (95%) Absent Reduced 2 4 5 6 27 - - 1 1 2 4 40 2 - 6 - - - -
T-02-Dx   Present Reduced - - - 2 3 - - - - - 1 2 90 - 2 - - - -
T-LBL* T-03-Dx Low, normal (50 - 60%) Present Normal 3 6 8 10 8 6 - 1 1 5 21 4 8 - 16 - - - 3
Non-leukemic NL-01 Low, normal (50-60%) None Adequate - 10 18 9 18 2 - 2 - - 16 - 0 - 25 - - - -
NL-02 Reduced None Reduced, normal 1 8 3 2 7 2 1 2 1 6 18 9 3 - 36 - - - 1
  1. Dx diagnosis, R Relapse, * = T-cell lymphoblastic lymphoma (T-LBL)
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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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