|
1
|
B-ALL Dx
|
Primary
| |
|
B-02-Dx
|
ETV6-RUNX1 fusion
|
|
SNV: SUZ12 lys690fs, 0.03
|
|
PDX
| |
|
B-02-Dx-PDXb
|
ETV6-RUNX1 fusion
|
|
CNV: SOCS2 (0.83), TET2 (0.97)
|
|
2
|
B-ALL R1
|
Primary
| |
|
B-05-R1
|
SNV: ARID1A (Gln563Ter, 0.33), KRAS (Lys117Arg, 0.35)
|
|
PDX
| |
|
B-05-R1-PDX
|
SNV: ARID1A Gln563Ter (0.49), KRAS Lys117Arg( 0.52)
|
|
CNV: FASLG (3.67), CDKN2A (0.85), CDKN2B (0.96)
|
|
3
|
B-ALL R3
|
Primary
| |
|
B-06-R3
|
SNV: JAK1 (Val658Phe, 0.48)
|
|
CNV: CDKN2A (0.07), CDKN2B (0.07), PTCH1(0.79), EBF1(1.0)
|
|
PDX
| |
|
B-06-R3-PDXb
|
SNV: JAK1 (Val658Phe, 0.99)
|
|
CNV: CDKN2A (0), CDKN2B (0), PTCH1 (0.76), EBF1 (1.0)
|
|
4
|
B-ALL R3
|
Primary
| |
|
B-07-R3
|
SNV: KRAS Gln61His (0.13)
|
|
CNV: CDKN2A (0.52), RB1 (0.85), P53 (1.37)
|
|
PDX
| |
|
B-07-R3-PDXa
|
SNV: KRAS Gln61His (0.4)
|
|
CNV: CDKN2A (0.33), RB1 (0.22), P53 (1.1)
|
|
5
|
T-ALL Dx
|
Primary
| |
|
T-02-Dx
|
STIL-TAL1 fusion
|
|
SNV: PTEN (Leu247fs, 0.2)
|
|
PDX
| |
|
T-02-Dx-PDX
|
STIL-TAL1 fusion
|
|
6
|
T-ALL Dx
|
Primary
| |
|
T-01-Dx
|
CNV: CDKN2A (0.6)
|
|
PDX
| |
|
T-01-Dx-PDX
|
CNV: CDKN2A (0.03)
|
