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Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: NOX1 inhibition attenuates the development of a pro‐tumorigenic environment in experimental hepatocellular carcinoma

Fig. 6

NOX1 inhibition attenuates the induction of angiogenic and fibrotic markers during HCC development. After 25 weeks of DEN administration and 15 weeks of vehicle/GKT771 treatment, HCC lesions and non-tumoral surrounding liver tissue were sampled for mRNA expression analysis. RT-qPCR was performed to determine the expression of a different angiogenic markers (CD31, END, iCAM and vCAM) and b fibrotic markers (αSMA, COL1A and TGFβ). Data shown as mean ± SEM. nsnot significant; * p < 0,05; ** p < 0,01; *** p < 0,001; ****p < 0,0001 compared to vehicle-treated healthy controls, unless indicated differently. c Sirius red staining of the livers of DEN-induced HCC mice receiving preventive GTK771 treatment was performed and Metavir scoring was compared to vehicle treated HCC mice. Data shown as individual scoring points with median. Metavir score: F0 - no fibrosis; F1 - fibrosis exists with expansion of portal zones; F2 - : fibrosis exists with expansion of most portal zones, and occasional bridging

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