Fig. 2

Eicosanoids profiling in triple negative breast cancer (TNBC) reveals miR-155 positively correlates with PGE2/PGD2 ratio and related metabolic enzyme expression. a Expression-correlation analysis of miR-155 (in blue) and PGE2/PGD2 ratio (in red) measured in human TNBC specimens (n = 20). b-e Relative RNA expression of PTGES1(b), PTGES2(c), PTGDS(d) and 15-PGDH(e) in miR-155-high (H1-H10, in red) and miR-155-low (L1-L10, in blue) TNBC specimens (n = 20). f Western blot results of key metabolic enzymes and suggested novel regulators for PGE2/PGD2 metabolism in the miR-155-high and -low TNBC specimens. Results of COX1, COX2, PTGES1, PTGES2, PTGDS and 15-PGDH are shown. g, h Correlation analysis between miR-155 and PGE2(g) or PGD2(h) level in the plasma samples of TNBC patients