Fig. 1
From: Targeting dopamine receptor D2 as a novel therapeutic strategy in endometrial cancer
The expression of DRD2 in human ECs. The expression of DRD2 was detected by immunohistochemistry in 118 human tissues of serous and endometrioid ECs (a). Using median composite H-scores, DRD2 expression demonstrated statistically significant positive association with grade, stage, histologic types, PFS and OS in ECs (b and c). Identification of DRD2 mRNA expression from TCGA database in 371 human endometrial tumors based on histology (d) and molecular subtypes (e). High expression of DRD2 was found in serous-like copy-number high subtype when compared to the other subtypes. CN Low: Copy number low. CN high: Copy number high. MSI: Microsatellite Instability