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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: Targeting dopamine receptor D2 as a novel therapeutic strategy in endometrial cancer

Fig. 4

ONC201 induced cellular stress in EC cells. The ECC-1 and KLE cells were treated with ONC201 at indicated doses for 24 h and ROS production was assessed by DCFH-DA assay. ONC201 increased ROS production in a dose dependent manner in both cell lines (a). The cell lysates underwent Western blotting analysis for PERK, Bip, PD-1, Erol-1 and IRE1-a in both cells after 24 h treatment with ONC201. The results showed that ONC201 increased the expression of PERK, Bip, PD-1, Erol-1 and IRE1-a (b). The levels of α-tubulin served as protein loading controls. Data are representative of three or more independent experiments. *p < 0.05 and **p < 0.01

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