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Fig. 7 | Journal of Experimental & Clinical Cancer Research

Fig. 7

From: Targeting dopamine receptor D2 as a novel therapeutic strategy in endometrial cancer

Fig. 7

The effect of ONC201 on metabolites in the LKB1fl/fl/p53fl/fl mouse model of EC. Metabolomic profiling were analyzed from the four groups (N = 5/group) by Metabolon. Endometrial tumors were found that lipid and protein biosynthesis were upregulated in the ECs of obese mice compared to lean mice. ONC201 increased lipid degradation and oxidation (a) and eicosanoid production in the ECs of obese mice but not lean mice (b). In contrast, ONC201 reduced glycolysis in the ECs of lean mice but not in the ECs of obese mice (b). ONC201 decreased protein biosynthesis in the ECs of both obese and lean mice (c). Red indicate metabolites with higher mean levels at a p ≤ 0.05 significance. Green cells indicate lower levels relative to control group at a p ≤ 0.05 significance. Data are presented as relative measures of “scaled intensity” and median scaling to 1

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