Fig. 1

USP16 is highly associated with c-Myc gene signature. a A volcano plot presents the differentially expressed genes between control and c-Myc-overexpressing PCa cells. b Venn diagram showing USPs that were positively correlated with the c-Myc gene signature in PCa datasets. USP numbers are labelled inside each of the ovals. c Knockdown efficiency of shRNAs is shown. d Western blot analysis of PC3 cells transfected with indicated shRNAs. e Plots indicating a significant positive correlation between USP16 and the c-Myc gene signature in four independent PCa datasets