Fig. 6

USP16 regulates PCa cell proliferation via c-Myc. a Expression of USP16 and c-Myc was evaluated by Western blot. b and c PC3 cells were transfected with the indicated plasmids and cell growth was measured by colony formation assay. d and e Cell viability was determined by CCK-8 assay. f Bubble plot of GSEA results. g and h Gene expression profiles of PC3 cells with or without knockdown of USP16 based on the Myc target and signature gene set