Fig. 7

USP16 expression is upregulated in prostate cancer. a Expression of POH1 in normal prostate tissues (N) and PCa tissues (T) were examined by IHC (Mann-Whitney test, p < 0.001). b Distribution of USP16 expression among prostate samples as indicated (N, normal prostate; low GS, Gleason scores ≤3 + 4; high GS, Gleason scores ≥4 + 3; weak, IHC scores ≤4; mod, 4 < IHC scores ≤8; strong, IHC scores > 8) (χ2 test; p < 0.05). c Representative images of prostate samples (scale bar: 100 μm). d Case A: a representative sample with high USP16 and c-Myc staining. Case B: a representative sample with low USP16 and c-Myc staining. Scale bar: 100 μm. e Quantification of the staining revealed a statistically significant correlation. (χ2 test; p < 0.01); f Correlation between USP16 and c-Myc expression in PCa samples are shown (Spearman correlation test; p < 0.001). R indicates the correlation coefficient