What is the prospect of indoleamine 2,3-dioxygenase 1 inhibition in cancer? Extrapolation from the past

Table 2 Comparison of all initiated clinical trials by cancer type^a

^a28 out of 98 trials that did not specifically indicate the target tumor type or enrolled healthy volunteers were excluded, and multiple cancar types could be tested in one trial. ^bOvarian cancer, endometrial carcinoma, primary peritoneal carcinoma, and fallopian tube cancer were classified as gynecological tumors. ^cBladder cancer was classified as urothelial carcinoma. ^dGlioma, glioblastoma, medulloblastoma, ependymoma were classified as brain tumors. ^eOthers include breast cancer [5], CRC [4], RCC [4], gastric cancer and/or esophageal cancer [4], acute myeloid leukemia (AML) [3], pancreatic carcinoma [3], HCC [2], prostate cancer [2], diffuse large B-cell lymphoma (DLBCL) [1], gastrointestinal stromal tumor [1], myelodysplastic syndromes [1], nasopharyngeal carcinoma (NPC) [1], rectal cancer [1], sarcoma [1] and thymic carcinoma [1]

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