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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: Cytosolic sensor STING in mucosal immunity: a master regulator of gut inflammation and carcinogenesis

Fig. 4

STING-dependent antitumor effect in gastrointestinal cancer. Dying tumor cells (1) could release a large amount of DNA (2); tumor-derived DNA are engulfed by DCs, and activates STING-dependent type I IFN response in the phagocyte (3), which facilitates cross-presentation and antitumor CD8+ T responses (4). Type I IFNs was also showed to suppress the function of immune suppressive cell such as Tregs cells and MDSCs, and induce the activation of NK cell (4), which play an important role in the destruction of tumor cells and antitumor immunity (5). DCs, dendritic cells

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