Type of PTMs | Sites | Enzyme | Consequences | Ref |
---|---|---|---|---|
STING protein | ||||
 Phosphorylation | Y245 | SRC | dimerization and stability of STING | 26 |
S358 | TBK1 | Recruitment of TBK1 | 27 | |
S366 | TBK1 | Recruitment of IRF3 | 27 | |
S366 | ULK1 | Induces degradation of STING | 28 | |
 Dephosphorylation | Y245 | PTPN1/2 | Degradation by a proteasome pathway | 29 |
S358 | ULK1 | Suppression of STING activity | 30 | |
Ubiquitination | ||||
 K11-linked polyubiquitination | K150 | RNF26 | Promotes stability of STING | 31 |
 K27-linked polyubiquitination | K137/150/ 224/236 | AMFR | Promotes recruitment of SITNG | 32 |
 K63-linked polyubiquitination | K20/150/ 224/236 | TRIM32 | promotes the interaction of STING with TBK1 | 33 |
 K63-linked polyubiquitination | K224/236/ 289/338 | MUL1 | Enhances trafficking of STING | 34 |
 K63-linked polyubiquitination | K150 | TRIM56 | Recruitment of TBK1 and induction of INF-β | 35 |
 K48-linked polyubiquitination | K275 | TRIM30α | Proteasomal degradation of STING | 36 |
 K48-linked polyubiquitination | K150 | RNF5 | Proteasomal degradation of STING | 37 |
 Palmitoylation | C88/91 | DHHC | Enhances trafficking of STING and type I IFN response | 38 |
 Nitro- alkylation | C88/91 | N.D. | Inhibits normal palmitoylation process | 39 |
 Carbonylation | C88 | GPX4 | inhibition of STING trafficking from the ER to the Golgi | 40 |
 Sumoylation | K338 | TRIM38 | Promotes oligomerization and stability of STING | 41 |
 Desumoylation | K388 | SENP2 | Lysosomal degradation of STING | 41 |
 Oxidation | C147 | ROS | Inhibition of STING polymerization | 42 |