Fig. 5

EIF4G2 is negatively regulated by miR-144. a Putative binding sites between miR-144 and EIF4G2-WT or EIF4G2-MUT 3’UTR position. b Luciferase reporter vectors of EIF4G2-WT or EIF4G2-MUT and miR-144 overexpression vectors were co-transfected into 293 T cells. Relative luciferase activity was assessed 48 h later. (C) Western blot analysis of EIF4G2 level. d The expression of miR-144 in HCC tumor tissues and matched para-cancer tissues. e Pearson association analysis of the miR-144 level and EIF4G2 protein expression. **p < 0.01, ****p < 0.0001 WT: the wild-type vector, MUT: the mutant vector