Fig. 1

Overexpression of LINC00460 is observed in CRC and correlates with poor prognosis. a Heatmap of top 50 dysregulated lncRNAs identified from microarray analysis. NCTs: Normal colon tissues. b LINC00460 expression was quantified in colorectal cancer tissues and their adjacent non-cancerous tissues in a small cohort (n = 57, p = 0.0048). b LINC00460 expression was validated in 8 pairs of CRC patient samples by PCR and gel electrophoresis, N, normal tissue; T, tumor. c representative images of LINC00460 expression in colorectal cancer and adjacent normal tissues using ISH analysis in large cohort (n = 498). d Staining intensities of LINC00460 in colorectal cancer tissues compared with paired adjacent non-cancerous tissue. N, paired adjacent non-cancerous tissues. C, colorectal cancer tissues (n = 464, p < 0.001). e, f Kaplan–Meier survival curves depicting overall survival (n = 498, p < 0.0001) or disease-specific survival of patients with CRC (n = 340, p < 0.001) stratified by LINC00460 expression levels in CRC tissues. g, h, i The GEO date of LINC00460 expression was in CRC correlated with poor survival in over survival, disease-free survival, and advanced tumor stage (GSE40967)