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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: HOXA10 mediates epithelial-mesenchymal transition to promote gastric cancer metastasis partly via modulation of TGFB2/Smad/METTL3 signaling axis

Fig. 5

HOXA10 modulated TGFβ signaling pathway principally by regulating TGFB2 in GC. a The protein expression in AGS-HOXA10 cells after TGFβ inhibitor (HY-N0439) treatment. b-c The mRNA or protein levels of TGFB1, TGFB2 and TGFB3 in different GC cells with modified HOXA10 expression. d The alteration of migratory and invasive abilities in AGS-HOXA10 cells after being treated with TGFβ, TGFβ1 or TGFβ2 inhibitor. e The alteration of migratory and invasive abilities in BGC823-shHOXA10 cells with treatment of hTGFβ2. f The protein expression in AGS-HOXA10 cells after TGFβ2 inhibitor (HY-N0673) treatment or in BGC823-shHOXA10 cells after the treatment of hTGFβ2 cytokine. Original magnification, 200×. ***P < 0.001

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