Fig. 1

FAM3C and MET CNs are tightly linked, correlate with gene expression and survival in lung cancer. a, d Summary of MET, FAM3C, EGFR and FGFR1 copy number calls extracted from lung squamous cell carcinoma (LUSC, a) and lung adenocarcinoma (LUAD, d) TCGA datasets. Genomic localization is marked above the genes. GISTIC 2.0 values were obtained from the cBio database (http://www.cbioportal.org/): − 2, deep deletion (DD); − 1, shallow deletion (SD); 0, diploid (Dipl); 1, gain; 2, amplification (Amp). Numbers within the boxes refer to the number of tumors within a group. Orange connection lines indicate tumor samples with FAM3C gain or amplification. Correlation was calculated using Kendall’s tau-b test. b, e mRNA expression levels of MET and FAM3C copy number calls defined in A and D. Statistical significance was determined by one-way analysis of variance (ANOVA) followed by Dunn’s multiple comparison adjustment and marked with asterisks (*p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001). c, f Kaplan-Meier plot on relapse-free survival of LUSCC (c) and LUAD (f) patients without (DD_SD-Dipl_Gain) and with (Amp) FAM3C and MET amplification