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Fig. 2 | Journal of Experimental & Clinical Cancer Research

Fig. 2

From: The FAM3C locus that encodes interleukin-like EMT inducer (ILEI) is frequently co-amplified in MET-amplified cancers and contributes to invasiveness

Fig. 2

Increased FAM3C and MET CNs are frequently combined and present in human cancer cell lines. a Percentage of cell lines bearing increased FAM3C and/or MET gene CNs (amplification cut-off was set CN ≥ 3) determined by GeneChip® Mapping Assay in a panel of 200 cancer cell lines of diverse tissue origin. Left panel (#), percentage of cell lines with increased FAM3C and/or MET CNs; right panel (##), percentage of combined FAM3C and MET CN increase within the FAM3C- and/or MET-amplified cell lines. Number of analyzed cell lines for each tumor entity are listed on the right side. Correlation, marked for LUNG, BREAST, COLON and TOTAL, was calculated using Kendall’s tau-b test. WBC; white blood cell. b Short-list of five selected human tumor cell lines from panel A with increased FAM3C and MET CNs and different sensitivity to the MET inhibitor PHA665752. MET CNs in brackets and % viability after PHA665752 treatment are taken from [19]. c Western blot analysis of ILEI secretion into conditioned media (CM) and expression within the cells and MET and Erk expression and activity in above five selected cell lines. MCF-7 and MDA-MB-231 human breast cancer cell lines were used as normal FAM3C CN controls with low and high ILEI expression

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