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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: Down-regulation of the tumor suppressor miR-34a contributes to head and neck cancer by up-regulating the MET oncogene and modulating tumor immune evasion

Fig. 1

p53 mutation and chr1p deletion correlate with decreased miR-34a expression. a through c: miR-34a expression versus p53 mutation status in patient tumors across 33 cancer types in the cancer genome atlas (TCGA) pan-cancer dataset (n = 9151) (a), squamous cell carcinomas (SCCs) (n = 1293) (b), or head and neck squamous cancers (HNSCCs) (n = 490) (c). d through g): miR-34a expression versus chromosome 1p copy number in p53 WT tumors, across cancer (n = 7792) (d), across SCCs (n = 380) (e), in lung squamous cell carcinomas (n = 57) (f), or HNSCCs (n = 141) (g). h Genes whose expression significantly correlated with miR-34a expression were analyzed by gene set enrichment analysis (GSEA) in HNSCC samples (n = 497). The plot shows the top enriched hallmark pathway, Epithelial-Mesenchymal Transition (EMT). Y-axis is the GSEA enrichment score. The X-axis is a list of genes ranked by differential expression correlation with miR-34a, with black bars representing genes in the EMT gene set. Data is presented in box and whisker plots, with whiskers representing minimum and maximum. * indicates p < 0.05; *** indicates p < 0.001

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