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Fig. 3 | Journal of Experimental & Clinical Cancer Research

Fig. 3

From: Down-regulation of the tumor suppressor miR-34a contributes to head and neck cancer by up-regulating the MET oncogene and modulating tumor immune evasion

Fig. 3

Levels of miR-34a negatively correlate with MET, and MET is overexpressed in head and neck squamous cancer (HNSCC). a Immunohistochemistry of MET expression in normal tissue, dysplastic tissue, and HNSCC tissue. b The percentage of MET positive cells were quantified in normal tissue, oral dysplasia, and HNSCC. c Levels of miR-34a-5p levels were quantified in high MET mRNA HNSCC cases versus low MET mRNA HNSCC cases. d Correlation of MET expression and miR-34a levels in over 497 HNSCC cancers in the TCGA dataset (R = -0.38, p < 0.0001) (e) Cumulative survival of HPV+ HNSCC cases with high MET mRNA compared to low MET mRNA in TCGA database (n = 497). Data represent results of at least three independent experiments. * indicates p < 0.05. **** indicates P < 0.0001

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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