Fig. 11

ITPR3 knockdown suppressed BCa cell distant metastasis in vivo. a Schematic diagram of the tail vein injection metastasis model in nude mice. b Representative bioluminescence images from the shITPR3 and shCon groups are shown in the left panel. c The histological changes detected by HE staining of the lungs from the shITPR3 and shCon groups are shown in the right panel. Arrows: foci of lung metastasis. d The general appearance of the lungs from the shITPR3 and shCon groups is presented in the left panel. e The number of lung surface metastatic lesions from the shITPR3 and shCon groups was also calculated. f The body weight changes in the shITPR3 and shCon groups were measured and recorded every three days. g Representative images of immunohistochemistry staining of ITPR3, CD44, E-cadherin, N-cadherin and IKBa are presented below. The scale bar represents 50 μm