Fig. 1

RBM15 was overexpressed in LSCC and associated with poor prognosis. a Global RNA m6A methylation was evaluated by the m6A RNA Methylation Quantification Kit. b Heatmap of differentially expressed genes in LSCC identified by mRNA-seq. c Protein Cluster Analysis heatmap of significantly differentially expressed proteins in LSCC tissues and adjacent nontumor tissue. d qRT-PCR assay verified the expression of RBM15 in 34 pairs of LSCC specimens. e The expression level of RBM15 was related to the clinicopathological characteristics of LSCC patients. f Expression levels of RBM15 in NHBEC and LSCC cell lines were examined using RT-qPCR. g Kaplan–Meier analysis of Overall Survival in HNSC patients. h Kaplan-Meier survival analysis of 122 LSCC tumour specimens showed that high RBM15 expression levels were significantly associated with poor OS. i Representative image of IHC staining of RBM15 in 122 LSCC tumour specimens